One of the aims of noisy neuron models is to mimic the large variability of interspike intervals found, e.g., in vertebrate cortex. To arrive at broad interval distributions, it is not just sufficient to introduce noise into a neuron model. Apart from the noise level, other neuronal parameters such as the firing threshold or a bias current have to be tuned so as to make the neuron sensitive to noise. In this section we introduce a distinction between super- and subthreshold stimulation (7; 470; 283; 520; 82).
An arbitrary time-dependent stimulus is called subthreshold, if it generates a membrane potential that stays – in the absence of noise – below the firing threshold. Due to noise, however, even subthreshold stimuli can induce action potentials. Stimuli that induce spikes even in a noise-free neuron are called superthreshold.
The distinction between sub- and superthreshold stimuli has important consequences for the firing behavior of neurons in the presence of noise. To see why, let us consider a leaky integrate-and-fire neuron with constant input for . Starting from , the trajectory of the membrane potential is
In the absence of a threshold, the membrane potential approaches the value for . If we take the threshold into account, two cases may be distinguished. First, if (subthreshold stimulation), the neuron does not fire at all. Second, if (superthreshold stimulation), the neuron fires regularly. The interspike interval is derived from . Thus
We now add diffusive noise. In the superthreshold regime, noise has little influence, except that it broadens the interspike interval distribution. Thus, in the superthreshold regime, the spike train in the presence of diffusive noise, is simply a noisy version of the regular spike train of the noise-free neuron.
On the other hand, in the subthreshold regime, the spike train changes qualitatively, if noise is switched on; see (283) for a review. Stochastic background input turns the quiescent neuron into a spiking one. In the subthreshold regime, spikes are generated by the fluctuations of the membrane potential, rather than by its mean (7; 470; 520; 82; 148). The interspike interval distribution is therefore broad; see Fig. 8.7.
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